主 题: A Simulation Study of Dynamic Model Based Algorithm for Affymetrix SNP Data
报告人: Prof. Hsun-Chih Kuo (National Chengchi University, Taiwan)
时 间: 2006-10-23 下午 3:30 - 4:30
地 点: 理科一号楼 1418
It is known that there is only 0.1% in the DNA sequences that is different among human
beings, and the rest of them are the same. These differences in DNA sequences are defined as
SNPs (Single Nucleotide Polymorphism). The Affymetrix, Inc. had developed a DNA chip
technology called Affymetrix GeneChip Mapping 100K SNP Set for SNP data. The default
algorithm applied by Affymetrix, Inc. to decide genotype calls is called the Dynamic Model-
based (DM) algorithm. In order to conduct DM algorithm, one has to compute the minimum log
likelihood ratio (S value) first. In this study, four different modified S values for the DM
algorithm were investigated. In addition, simulated SNP data were used to assess the
performance of the DM algorithms based on different modified S values.
